Public Health Articles » tadalafil

Tadalafil (Cialis)

CheTeam — Thu, 03 Mar 2011 15:11:55 +0000

treat male erectile dysfunction (impotence), developed by the biotech firm ICOS and marketed worldwide by Eli Lilly. Cialis has FDA approval and appeared in
U.S. stores in December, 2003. Cialis has a multiyear promotional deal with professional golf ‘s PGA TOUR. The tablets are yellow and oval-shaped.
Cialis’s main selling points are that it works for up to 36 hours after being swallowed and that it can be taken with or
without food (Viagra works for some 4 hours). It has the same mode of action as sildenafil (Viagra), and vardenafil (Levitra).
12–24 hours after taking the drug. These side effects usually go away after a few hours, though back pain and muscle aches
Men taking nitrates or alpha blockers should not take Cialis because it could cause blood pressure problems. Some of the side
effects of the drug include back ache, stomach ache, muscle aches, or headaches. The company advises that in the rare event that

Tadalafil (Forzest)

CheTeam — Wed, 01 Sep 2010 15:23:32 +0000

Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. It works by inhibiting an enzyme known as PDE5. Due to its 36-hour effect it is also known as the “Weekend Pill”. In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003.
The empirical formula for tadalafil is C 22 H 19 N 3 O 4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazinopyridoindole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of sildenafil (Viagra).
The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.
In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, e.g. diabetics. An investigation is currently ongoing.
In the United States, Eli Lily has a multiyear agreement to promote tadalafil (Cialis) with professional golf ‘s PGA TOUR.

Tadalafil (Tadacip)

CheTeam — Wed, 01 Sep 2010 15:20:04 +0000

Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis.
In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third impotence pill after sildenafil (Viagra) and vardenafil (Levitra). Due to its 36-hour effect it is also known as the weekend pill. It should be noted that the drug has not been formally studied in regard to multiple sexual attempts during a 36 hour period.
The history of Cialis cannot be discussed without mentioning Pfizer’s drug, Viagra. The FDA’s approval on March 27, 1998, led this prescription drug, Viagra, to a ground breaking success in just the first year of introduction as Pfizer sold drugs worth over a billion dollars. However, things changed considerably for the giant of erectile dysfunction drugs when the FDA also approved Levitra on August 19, 2003, and Cialis on November 21, 2003. In 1993 the drug company Icos began studying IC351, which is a PDE5 enzyme inhibitor, and this is basically the process through which the erectile dysfunction drugs work. In 1994, Pfizer scientists discovered that sildenafil citrate, which is a white crystalline powder that temporarily normalizes erectile function of the penis by blocking an enzyme known to inhibit the production of a chemical that causes erections, caused the heart patients that were participating in a clinical study of a heart medicine to have erections. Although the scientists were not testing the chemical compound IC351 for erectile dysfunction, the compound seemed to have a side effect which could potentially be worth millions, if not billions of dollars. Soon Icos received its very first patent in 1994 on IC351, and the clinical trials of phase 1 took place in 1995. In 1997, phase 2 clinical studies began and Icos performed its first study on patients with erectile dysfunction. Phase 2 lasted about two years, and after that phase 3 began.
In 1998, ICOS Corporation, and Eli Lilly and Company, commercialized the drug for erectile dysfunction, and two years later they filed a new drug application with the U.S. Food and Drug Administration for IC351; the only difference was that this time they decided to call the drug Cialis. In May of 2002, Icos and Eli Lilly and Company reported to the American Urological Association that the phase 3 tests show that Cialis works for up to 36 hours, and one year later Icos and Eli Lilly and Company received the U.S. FDA’s approval for Cialis. One advantage that Cialis has over Viagra is that tadalafil has a half-life of 17.5 hours (and thus Cialis is advertised to work for up to 36 hours, after which time there is still about one quarter of the absorbed dose in the body) as compared to 4 hours half-life for sildenafil (Viagra).
The empirical formula for tadalafil is C 22 H 19 N 3 O 4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazinopyridoindole-1,4-dione. The molecular weight is 389.41. Tadalafil tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20 mg doses.
Tadalafil works by inhibiting PDE5, an enzyme found primarily in the arterial wall smooth muscle tissue of the penis and the lungs. A 20 mg dose of tadalafil is comparable to a 100 mg dose of sildenafil (Viagra). By inhibiting PDE5, tadalafil relaxes blood vessels in the penis, thereby increasing blood flow and aiding in erection.
Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection.
Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of tadalafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, tadalafil should not cause an erection. Other drugs that operate by the same mechanism include sildenafil (Viagra®) and vardenafil (Levitra®).
Tadalafil is currently undergoing clinical trials for the treatment of pulmonary hypertension. The clinical trials are based on tadalafil’s inhibitiong of PDE5. It is hoped that by inhibiting this enzyme, tadalafil will prove effective in opening up blood vessels in the lungs, lowering pulmonary arterial resistance and pressure, and thus reducing the workload of the right ventricle of the heart.
The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.
In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, including diabetics. An investigation is currently ongoing.
Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates (such as the sex drug amyl nitrite) within this timeframe may increase the risk of life-threatening hypotension.
Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina (such as glyceryl trinitrate spray), these patients should seek immediate medical attention if they experience anginal chest pain. In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.
In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf ‘s PGA Tour.
Some individuals with the surname of “Cialis” objected to Lilly’s naming of the drug, but the company insists that the drug’s trade name has nothing to do with the surname.
^ Cialis – Safety Monitoring(s). Epocrates Rx software, produced by Epocrates, Inc.. Information also available online. Retrieved on 2007 – 04-06.
^ Viagra – Safety Monitoring(s). Epocrates Rx software, produced by Epocrates, Inc.. Information also available online. Retrieved on 2007 – 04-06.
^ Revill, Jo. ” Drugs giant says its new pill will pack more punch than rival Viagra “, The Observer, February 2, 2003. Retrieved on 2007 – 04-06.
Categories : Cleanup from September 2007 | All pages needing cleanup | All articles with unsourced statements | Articles with unsourced statements since February 2007 | PDE5 inhibitors | Lilly

CIALIS is not for everyone

admin — Fri, 08 Jan 2010 15:55:42 +0000

If you take nitrates, often used for chest pain (also known as angina), or alpha-blockers (other than Flomax 0.4 mg once daily), prescribed for prostate problems or high blood pressure, do not take CIALIS. Such combinations could cause a sudden, unsafe drop in blood pressure. Don’t drink alcohol in excess (to a level of intoxication) with CIALIS. This combination may increase your chances of getting dizzy or lowering your blood pressure. CIALIS does not protect a man or his partner from sexually transmitted diseases, including HIV.

The most common side effects with CIALIS were headache and upset stomach. Backache and muscle ache were also reported, sometimes with delayed onset. Most men weren’t bothered by the side effects enough to stop taking CIALIS. Although a rare occurrence, men who experience an erection for more than 4 hours (priapism) should seek immediate medical attention. Discuss your medical conditions and medications with your doctor to ensure CIALIS is right for you and that you are healthy enough for sexual activity.

*Individual results may vary. In clinical trials, CIALIS was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. CIALIS has not been studied for multiple sexual attempts per dose.

CIALIS® is a registered trademark of Lilly ICOS LLC.
Flomax® (tamsulosin HCl) is a registered trademark of its owner.